کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5409915 | 1506548 | 2016 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Binding interactions of anesthetic drug with surface active ionic liquid
ترجمه فارسی عنوان
تعاملات متداول داروهای بیهوشی با مایعات یونی سطحی فعال
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کلمات کلیدی
مایعات یونی، هیدروکلراید لینیدکائین، هدایت، کشش سطحی، فلورسانس،
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی تئوریک و عملی
چکیده انگلیسی
The application of aggregation behavior of a surface active ionic liquids (SAILs), 1-dodecyl-3-methylimidazolium chloride [C12mim][Cl] and 1-tetradecyl-3-methylimidazolium chloride [C14mim][Cl] in drug delivery of lidocaine hydrochloride has been investigated from surface tension and fluorescence measurements at 298.15 K and from conductance at 288.15, 298.15 and 308.15 K. Critical aggregation concentration (CAC), degree of ionization (α), and various thermodynamic parameters like Gibbs free energy of aggregation (â Gagg.°) standard enthalpy of aggregation (â Hagg.°) and standard entropy of aggregation (â Sagg.°) are calculated using conductivity measurements. The surface activity of the ILs in various mixed solvents are examined from surface tension measurements by calculating various surface parameters like maximum surface excess concentration (Ðmax), minimum surface area per ionic liquid molecule (Amin), adsorption efficiency (pC20), effectiveness of surface tension reduction (Î cac) surface tension at CAC (γcac), p (packing parameter), and CAC at different compositions. Fluorescence measurements have been employed to get detailed insight of the local microenvironment of the aggregates, and critical aggregation concentration (CAC). Decrease in the CAC values was observed with the increase in the amount of drug which is attributed to the balancing between electrostatic and hydrophobic interactions. This shows that the spontaneity of aggregation process of IL increases with the increase in the concentration of drug.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular Liquids - Volume 222, October 2016, Pages 471-479
Journal: Journal of Molecular Liquids - Volume 222, October 2016, Pages 471-479
نویسندگان
Amalendu Pal, Alka Yadav,