کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5410240 | 1506556 | 2016 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Development of clove oil based nanoemulsion of olmesartan for transdermal delivery: Box-Behnken design optimization and pharmacokinetic evaluation
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی تئوریک و عملی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The aim of this study was to develop and optimize a transdermal nanoemulsion formulation of olmesartan using Box-Behnken design and to evaluate it for pharmacokinetic study. Box-Behnken experimental design was applied for optimization of olmesartan nanoemulsions. The independent variables were clove oil (X1), Smix (X2) and water (X3) while particle size (Y1), polydispersity index (Y2) and olmesartan transdermal flux (Y3) were the dependent variables. Further the optimized formulation obtained was then tested in rats for an in vivo pharmacokinetic study. Results indicate that the developed nanoemulsion carrier of olmesartan provides reasonable particle size, polydispersity index and transdermal flux. The optimized formulation has presented the particle size of 53.11 ± 3.13 nm, polydispersity index 0.335 ± 0.008 and transdermal flux 12.65 ± 1.60 μg/cm2/h. Confocal laser scanning microscopy revealed an enhanced penetration of Rhodamine B loaded nanoemulsion carriers to the deeper layers of the skin. Furthermore, in vivo pharmacokinetic study of optimized formulation showed a significant increase in the bioavailability (1.23 times) compared with oral formulation of olmesartan by virtue of better permeation through rat skin. The developed nanoemulsion formulation could be used as an antihypertensive dosage form for effective transdermal delivery of olmesartan.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular Liquids - Volume 214, February 2016, Pages 238-248
Journal: Journal of Molecular Liquids - Volume 214, February 2016, Pages 238-248
نویسندگان
Mohd. Aqil, Mohd. Kamran, Abdul Ahad, Syed Sarim Imam,