The transfer of neutral molecules from water and from the gas phase to solvents acetophenone and aniline

We have used literature data to set out equations for the transfer of neutral solutes from water and from the gas phase to the dry solvents acetophenone and aniline. The equations contain five descriptors and can be used to predict further values of the water-acetophenone, gas-acetophenone, water-aniline and gas-aniline partition coefficients for a wide range of solutes with an error of about 0.2 log units. These equations provide information about the solubility properties of the two solvents. It is shown that acetophenone behaves as a typical aprotic aromatic solvent, albeit with a rather large hydrogen-bond basicity. Aniline behaves as a hydrogen-bond acidic solvent, stronger even than ethanol solvent. Since aniline solvent is also a moderately strong hydrogen-bond base, it has rather unusual solubility properties by comparison to other aromatic solvents.