Physically microstriped-nanoengineered polystyrene surface (PMS-NPS) for regulating cell attachment and alignment fabricated by nano-injection molding

• A physically microstriped-nanoengineered polystyrene surface (PMS-NPS) was proposed to control cell attachment and alignment.
• The PMS-NPS was mass-replicated by a nano-injection molding process with a metallic nano-mold insert.
• The PMS-NPS can control the MG-63 cell alignment by biophysical cue without biochemical cue.

In the present study, we developed a physically microstriped-nanoengineered polystyrene surface (PMS-NPS) to control cell attachment and alignment. The PMS-NPS was mass replicated by nano-injection molding with a rigid metallic nano-mold insert, which was cost-effectively manufactured by two-step anodization process, UV-photolithography, and electroforming process. In our previous result, attachment of MG-63 cells was found to be enhanced on the nanoengineered polystyrene surface (NPS) without any biochemical treatments. In this study, the PMS-NPS was proposed to control the cell attachment and alignment by biophysical cue without biochemical cue. Throughout this study, we were able to observe the enhanced MG-63 cell attachment and alignment on PMS-NPS compared to flat PS.

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