Electrocatalytic quantifaction of antitubarcular drug ethionamide in sodium lauryl sulfate

A novel voltammetric sensor has been developed with zirconia nanoparticles by drop casting method. Sensor was characterized with scanning electron microscopy (SEM) and X-ray diffraction (XRD) techniques. Electrochemical impedance spectroscopic (EIS) spectra exhibited decrease in charge transfer resistance, which indicates the good conductivity of the modified sensor as compared to bare glassy carbon electrode. Voltammetric behavior of ethionamide (ETA) on the developed sensor was investigated by cyclic voltammetry (CV) and square-wave voltammetric (SWV) methods and results indicated that the electrode process is diffusion controlled. Under optimized conditions, the peak current in SWV, increased linearly with the ethionamide (ETA) concentration in the range of 150-650 ng/mL and a limit of detection (LOD) was found to be 47.66 ng/mL.