Mixed micellization between amphiphilic drug promethazine hydrochloride and cationic surfactant (conventional as well as gemini)

► Micellization behaviors of amphiphilic drug-cationic surfactant combinations have been investigated. ► The negative β values suggest attractive interactions between the components. ► Temperature helps in tuning the aggregational behavior of a drug and its mixtures. ► For PMT/PMT-surfactant systems, ∆Hom values change from negative to positive with temperature.