Spectroscopic investigations on the inclusion interaction between hydroxypropyl-β-cyclodextrin and bupropion

► Hydroxypropyl- β-cyclodextrin (HP-β-CD) and bupropion (BUP) form inclusion complex. ► Main factors affecting the inclusion interaction we discussed in detail. ► The study was followed by UV and nuclear magnetic resonance (NMR) spectroscopy. ► A sensitive method for bupropion determination using HP-β-CD was proposed. ► The method was applied to BUP determination in pharmaceutical products.