کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5413329 | 1506622 | 2008 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The influence of the structural characteristics of the substrate and the medium on the stability of triflusal and acetylsalicylic acid in micellar systems
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی تئوریک و عملی
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چکیده انگلیسی
A spectrophotometric study of the alkaline hydrolysis of two salicylic acid (SA) derived drugs, performed on acetylsalicylic acid (ASA) and triflusal, both in the absence and presence of cationic micelles. In the absence of micelles, a catalytic effect is produced by the favoured OHâ ion in the molecule of triflusal, due to the presence of the trifluoromethyl group. The surfactants used were: hexadecyltrimethylammonium hydroxide (HDTAOH), hexadecyltrimethylammonium chloride (HDTACl), hexadecyltrimethylammonium bromide (HDTABr), hexadecylethyldimethylammonium bromide (HDEDABr) and tetradecyltrimethylammonium bromide (TDTABr). In micelles with reactive counterions, the pseudo-first-order rate constant (kobs) increases with the increase in surfactant concentration, while in micelles with non-reactive counterions, the rate constant increased with surfactant concentration at low concentration, reaching a maximum, and decreased at high surfactant concentration, even to below the value found in the absence of micelle. The micellar binding constant of both drugs (KS), the micellar rate constant (kM) and the ion-exchange constant (KXOH) were determined according to variation in kobs in relation to surfactant concentration, through the application of the pseudophase ion-exchange model (PPIE) proposed. The empirical parameters obtained were found to depend on the substrate and the surfactant structure, these parameters were: the counterion of the micelle, the size of the headgroup and the chain length of the hydrophobic tail of the surfactant.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular Liquids - Volume 142, Issues 1â3, 20 August 2008, Pages 64-71
Journal: Journal of Molecular Liquids - Volume 142, Issues 1â3, 20 August 2008, Pages 64-71
نویسندگان
M. Ferrit, C. del Valle, F. MartÃnez,