کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5433339 1508984 2017 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Combining amino amide salts in mucoadhesive films enhances needle-free buccal anesthesia in adults
ترجمه فارسی عنوان
ترکیبی از نمکهای آمینو آمید در فیلمهای موکوزاپسسی باعث افزایش بیحسی موضعی با سوزن در بزرگسالان می شود
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد بیومتریال
چکیده انگلیسی

Needle-phobia is usually a great concern in dentistry, and the replacement of painful injections by patient-friendly needle-free topical formulations would bring several advantages in dental practice worldwide. In this pursuit, the effects of combining prilocaine hydrochloride (PCL) and lidocaine hydrochloride (LCL) in different proportions in mucoadhesive films on their in vitro permeation and retention through porcine esophageal mucosa was studied. Complementarily, the permeation and retention of isolated LCL was investigated. The in vitro model used for evaluating buccal anesthetic penetration and retention in buccal epithelium was validated. In addition, the feasibility of a novel in vivo model to evaluate the painful sensation due to puncture “needle-shaped” gum jaw of adults at shallow and deep levels was demonstrated. The in vivo clinical survey revealed the efficiency of the films, which had onset of anesthesia at 5 min, peak of anesthetic effect within 15 and 25 min and anesthesia duration of 50 min after being placed in maxillary sites. The in vitro drug flux, permeability coefficient and retention in the epithelium significantly correlated with in vivo onset, peak and extent of shallow and deep anesthetic effect. At shallow level, the permeation of LCL has shown to be closely related to the onset of anesthesia, while the penetration of PCL has a significant impact in the peak of anesthetic effect. Concerning the deep level, the penetration of PCL is required to attain the onset of anesthetic effect. The total amount of drug retained in the epithelium showed to modulate the extent of both shallow and deep anesthesia. Thus, the combination of LCL and PCL in mucoadhesive films may offer dentists and their patients a safe improvement for pain management during dental procedures.

Mucoadhesive films containing prilocaine (PCL) and lidocaine (LCL) hydrochlorides were effective for decreasing the painful sensation due to puncture “needle-shaped” gum jaw of adults at shallow and deep levels.120

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Controlled Release - Volume 266, 28 November 2017, Pages 205-215
نویسندگان
, , , , , , ,