کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5433502 1508990 2017 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Singlet oxygen-responsive micelles for enhanced photodynamic therapy
ترجمه فارسی عنوان
میکسل واکنش اکسیژن واکنش پذیر برای افزایش فتودینامیک درمان
کلمات کلیدی
میشل، درمان فوتودینامیک، تک واکنش اکسیژن ایمیدازول، تحویل مواد مخدر،
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد بیومتریال
چکیده انگلیسی

Photodynamic therapy (PDT) efficacy is limited by the very short half-life and limited diffusion radius of singlet oxygen (1O2). We report a 1O2-responsive micellar nanoplatform subject to considerable size-expansion upon light triggering to facilitate on-demand release of photosensitizers. Imidazole, a well-known 1O2 scavenger, was incorporated in the hydrophobic core of amphiphilic copolymer micelles, and was used to coordinate with biocompatible Zn2 + and encapsulate the photosensitizer chlorin e6 (Ce6). The micelles are highly sensitive to light irradiation: 1O2 triggering induced dramatic particle size expansion due to the conversion of imidazole to hydrophilic urea, resulting in instantaneous release of Ce6 and rapid intracellular distribution. This 1O2-responsive, size-expandable nanosystem delivered substantially more Ce6 to tumor sites as compared to free Ce6, and exhibited improved anti-tumor efficacy in vivo in 4T1 tumor-bearing mice. This work opens new avenues of particle expansion-induced PDT enhancement by controlled imidazole chemistry.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Controlled Release - Volume 260, 28 August 2017, Pages 12-21
نویسندگان
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