کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5433851 1509001 2017 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
ApoE-modified solid lipid nanoparticles: A feasible strategy to cross the blood-brain barrier
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد بیومتریال
پیش نمایش صفحه اول مقاله
ApoE-modified solid lipid nanoparticles: A feasible strategy to cross the blood-brain barrier
چکیده انگلیسی

Solid lipid nanoparticles (SLN) are colloidal drug delivery systems characterized by higher entrapment efficiency, good scalability of the preparation process and increased sustained prolonged release of the payload compared to other nanocarriers. The possibility to functionalize the surface of SLN with ligands to achieve a site specific targeting makes them attractive to overcome the limited blood-brain barrier (BBB) penetration of therapeutic compounds. SLN are prepared for brain targeting by exploiting the adaptability of warm microemulsion process for the covalent surface modification with an Apolipoprotein E-derived peptide (SLN-mApoE). Furthermore, the influence of the administration route on SLN-mApoE brain bioavailability is here evaluated. SLN-mApoE are able to cross intact a BBB in vitro model. The pulmonary administration of SLN-mApoE is related to a higher confinement in the brain of Balb/c mice compared to the intravenous and intraperitoneal administration routes, without inducing any acute inflammatory reaction in the lungs. These results promote the pulmonary administration of brain-targeted SLN as a feasible strategy for improving brain delivery of therapeutics.

Solid lipid nanoparticles (SLN), prepared by warm microemulsion, are functionalized with a brain targeting peptide (mApoE). Intratracheally instilled SLN-mApoE translocate from the lungs to the brain crossing the blood-brain barrier.90

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Controlled Release - Volume 249, 10 March 2017, Pages 103-110
نویسندگان
, , , , , , , , , , , , ,