کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5434024 1509004 2017 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Photothermally triggered on-demand insulin release from reduced graphene oxide modified hydrogels
ترجمه فارسی عنوان
از نظر فوتوگرافی، تولید انسولین بر اساس تقاضا، از هیدروژلهای اصلاح شده اکسید گرافین کاهش یافته است
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد بیومتریال
چکیده انگلیسی

On-demand delivery of therapeutics plays an essential role in simplifying and improving patient care. The high loading capacity of reduced graphene oxide (rGO) for drugs has made this matrix of particular interest for its hybridization with therapeutics. In this work, we describe the formulation of rGO impregnated poly(ethylene glycol) dimethacrylate based hydrogels (PEGDMA-rGO) and their efficient loading with insulin. Near-infrared (NIR) light induced heating of the PEGDMA-rGO hydrogels allows for highly efficient insulin release. Most importantly, we validate that the NIR irradiation of the hydrogel has no effect on the biological and metabolic activities of the released insulin. The ease of insulin loading/reloading makes this photothermally triggered release strategy of interest for diabetic patients. Additionally, the rGO-based protein releasing platform fabricated here can be expanded towards 'on demand' release of various other therapeutically relevant biomolecules.

The table of contents entry: Poly(ethylene glycol) based hydrogels impregnated with rGO allow efficient loading and 'on demand' photothermal release of insulin while preserving its biological and metabolic activity.47

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Controlled Release - Volume 246, 28 January 2017, Pages 164-173
نویسندگان
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