کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5434385 1509143 2017 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mesoporous silica nanoparticles as potential carriers for enhanced drug solubility of paclitaxel
ترجمه فارسی عنوان
نانوذرات سیلیس مزوپور به عنوان حامل های بالقوه برای افزایش محلول پتاسیم در بسته بندی
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد بیومتریال
چکیده انگلیسی


- MSN were designed as carriers for water-insoluble PTX.
- The solubility of PTX was highly improved after loading into MSN.
- Drug loading capacity increased as the polar parameter of solvent decreased.
- Drug loading content increased as the drug/carrier mass ratio increased.
- The cytotoxicity of PTX loaded MSN increased as PTX concentration increased.

In this study, paclitaxel (PTX), a typical chemotherapeutic agent with poor water-solubility, was selected as the model drug to evaluate the feasibility of mesoporous silica nanoparticles (MSN) to load a hydrophobic drug in different solvents. A sol-gel method was used to synthesize MSN. Drug loading was carried out in three different solvents: dichloromethane, ethanol and dimethyl sulfoxide (DMSO) via a solvent evaporation method, and their effects on drug loading were examined. We further studied the effects of drug loading period and mass ratio of drug to carrier on drug loading capacity of MSN, as well as the in vitro drug release was analyzed. Moreover, the cytotoxic effect of PTX loaded MSN on liver carcinoma (HepG2) cells was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The related materials were characterized by scanning electron microscope (SEM), transmission electron microscope (TEM), dynamic light scattering (DLS), fourier transform infrared spectrometer (FTIR), small-angle x-ray scattering (SAXS), wide-angle x-ray diffraction (XRD) and N2 adsorption-desorption analyses. The results demonstrated a highly improved solubility of PTX by using MSN as drug carriers compared to free PTX. In addition, drug loading content increased as the solvent polarity parameter decreased or the drug/carrier mass ratio increased. Compared with the blank MSN, the PTX loaded MSN could produce a significant cytotoxicity on HepG2 cells. Our results indicated that MSN could be very potential drug delivery carriers for poorly water soluble drugs.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Materials Science and Engineering: C - Volume 78, 1 September 2017, Pages 12-17
نویسندگان
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