کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5434847 1509146 2017 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Ultrasound stimulated release of gallic acid from chitin hydrogel matrix
ترجمه فارسی عنوان
اولتراسوند باعث انتشار اسید گالیک از ماتریکس هیدروژل کیتین می شود
کلمات کلیدی
هیدروژل کیتین، گالیک اسید، سونوگرافی، تحویل مواد مخدر،
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد بیومتریال
چکیده انگلیسی


- Ultrasound (US) stimulated Gallic acid (GA) release from chitin hydrogel was studied.
- The release efficiency of GA from chitin hydrogel increased nine times when irradiated by 43 kHz US compared with the sample without US.
- Generalized 2D correlation and deconvolution study of FT-IR showed that US could promote the GA release by breaking hydrogen bonds.

Ultrasound (US) stimulated drug release was examined in this study using a chitin hydrogel matrix loaded with gallic acid (GA), a drug used for wound healing and anticancer. Using phase inversion, GA-chitin hydrogels were prepared from chitin-dimethylacetamide (DMAc)/lithium chloride (LiCl) solution in the presence of GA, with 24 h exposure of the solution to water vapor. The GA release from the GA-chitin hydrogel was examined under different US powers of 0-30 W at 43 kHz. The effects of GA loading amounts in the hydrogels (0.54, 0.43, and 0.25 mg/cm3) and chitin concentrations (0.1, 0.5, and 1 wt%) on the release behaviors were recorded under 43 kHz US exposure at 30 W. Results show that US accelerated the release efficiencies for all samples. Furthermore, the release efficiency increased concomitantly with increasing US power, GA loading amount, and decrease of the chitin concentration. The highest release rate of 0.74 μg/mL·min was obtained from 0.54 mg/cm3 of GA-loaded hydrogel fabricated from a 0.1 wt% chitin mixture solution under 43 kHz US exposure at 30 W: nine times higher than that of the sample without US exposure. The hydrogel viscoelasticity demonstrated that the US irradiation rigidified the material. FT-IR showed that US can break the hydrogen bonds in the GA-chitin hydrogels.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Materials Science and Engineering: C - Volume 75, 1 June 2017, Pages 478-486
نویسندگان
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