کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5451510 1398541 2016 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Controlling stem cell behavior with decellularized extracellular matrix scaffolds
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد شیمی مواد
پیش نمایش صفحه اول مقاله
Controlling stem cell behavior with decellularized extracellular matrix scaffolds
چکیده انگلیسی
Decellularized tissues have become a common regenerative medicine platform with multiple materials being researched in academic laboratories, tested in animal studies, and used clinically. Ideally, when a tissue is decellularized the native cell niche is maintained with many of the structural and biochemical cues that naturally interact with the cells of that particular tissue. This makes decellularized tissue materials an excellent platform for providing cells with the signals needed to initiate and maintain differentiation into tissue-specific lineages. The extracellular matrix (ECM) that remains after the decellularization process contains the components of a tissue specific microenvironment that is not possible to create synthetically. The ECM of each tissue has a different composition and structure and therefore has unique properties and potential for affecting cell behavior. This review describes the common methods for preparing decellularized tissue materials and the effects that decellularized materials from different tissues have on cell phenotype.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Solid State and Materials Science - Volume 20, Issue 4, August 2016, Pages 193-201
نویسندگان
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