Multi modality of hollow tube Gd2O3:Eu3+ nanoparticles by using nonpolar solvent

Gd2O3:Eu3+ is useful material in physics, chemical and biomedicine which can be applied to the magnetic resonance imaging (MRI) brightness, X-ray computed tomography (CT) as contrast agent and luminescence phenomenon as phosphor. In this paper, Gd2O3:Eu3+ was synthesized by one-step low cost solvothermal reaction with different ratio of solvents (De-ionized water (DI)/toluene (TL)). The alteration of solvent ratios affects the morphology (rod to hollow tube shape) and size of Gd2O3:Eu3+ which induce the property variation such as luminescence intensity, MR imaging and CT imaging brightness. The luminescence intensity of Gd2O3:Eu3+ nanoparticles with DI 40/TL 0 is much higher than the 1.48, 1.68, 1.73 and 1.75 times by others (DI 0/TL 40, DI 10/TL 30, DI 20/TL 20 and DI 30/TL 10), MR images of Gd2O3:Eu3+ with DI 0/TL 40 were shown to be 2.5 times brighter than that of the commercial contrast agent (Dotarem) and CT images of Gd2O3:Eu3+ with DI 0/TL 40 was 1.68 times brighter than Dotarem. Gd2O3:Eu3+ prepared with different solvent ratios can be selectively applied for potential applications as MRI, CT and FI multimodal imaging agent.