کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5498148 | 1533329 | 2017 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The relationship between dosimetric factors, side effects, and survival in patients with non-small cell lung cancer treated with definitive radiotherapy
ترجمه فارسی عنوان
ارتباط بین عوامل دوزیمتری، عوارض جانبی و بقا در بیماران مبتلا به سرطان ریه غیر سلولی تحت درمان با رادیوتراپی قطعی
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موضوعات مرتبط
مهندسی و علوم پایه
فیزیک و نجوم
تشعشع
چکیده انگلیسی
The patients with non-small cell lung cancer (NSCLC) treated with definitive conformal radiotherapy (RT) were evaluated in terms of side effects and survival. Normal tissue complication probability (NTCP) was calculated for 68 patients treated between 2009 and 2012. Clinical and dosimetric factors were analyzed. The median dose of 63âGy (range: 54 to 70âGy) was given with conformal RT with blocks (nâ=â37), 3-dimensional conformal RT (3DCRT) (nâ=â11), or intensity-modulated RT (IMRT) (nâ=â20). Acute grade 1 to 2 radiation pneumonitis (RP) was seen in 13% of the patients. No significant relationship was found between RP and treatment and dosimetric factors (pâ>â0.05). There was a positive correlation between median “mean lung dose” (MLD) (17âGy), lung V30 (20.5%), and NTCP (14%) (pâ<â0.001). Median and 2-year overall survival (OS) and progression-free survival (PFS) were 27 and 18 months and 51% and 42%, respectively. In univariate analysis, significant dose range for survival was found between 59.4 and 63âGy (pâ<â0.01). In multivariate analysis, response (pâ=â0.001), fraction dose of 1.8âGy (pâ=â0.002), MLD <18âGy (pâ=â0.04) for OS and response (pâ<â0.001), total doseâ>â59.4âGy (pâ=â0.01), and tumor biologically effective dose (BED)3(Gy)ââ¤â100.8 (pâ=â0.01) for PFS were found to be favorable factors. In our study, we found a linear correlation between NTCP and MLD for RP risk estimation in patients with NSCLC. Therapeutic dose range where MLD can be kept under 20âGy with significant survival benefit was found between 59.4 and 63âGy. Increased therapeutic efficacy will be possible using risk-adaptive RT techniques.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Medical Dosimetry - Volume 42, Issue 3, Autumn 2017, Pages 169-176
Journal: Medical Dosimetry - Volume 42, Issue 3, Autumn 2017, Pages 169-176
نویسندگان
Dilruba M.D., Sureyya M.D., Sema M.S., Deniz Ph.D.,