Recombinant tissue plasminogen activator enhances microparticle release from mouse brain-derived endothelial cells through plasmin

This study demonstrates that rt-PA induces the production of microparticles by cerebral endothelial cells, through plasmin, p38 MAPK and PARP pathways. Determining the phenotype of these EMPs to clarify their role on the endothelium in ischemic conditions could thus be of particular interest.