کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5504924 | 1400257 | 2017 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synergistic effects of combination treatment using EGCG and suramin against the chikungunya virus
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Synergistic effects of combination treatment using EGCG and suramin against the chikungunya virus Synergistic effects of combination treatment using EGCG and suramin against the chikungunya virus](/preview/png/5504924.png)
چکیده انگلیسی
Chikungunya is a severe disease that results from infection with the chikungunya virus (CHIKV), an arbovirus. Thus, we (1) explored a new approach to combining previously researched drugs that have shown the potential to inhibit CHIKV infection; and (2) demonstrated the antiviral effects of (â)-Epigallocatechin-3-gallate (EGCG) and the underlying mechanisms. Specifically, we used U2OS cells infected with CHIVK to assess the synergistic antiviral activities of EGCG and suramin. EGCG presented the ability to inhibit the viral RNA, progeny yield, and cytopathic effect (CPE) of CHIKV and also demonstrated the ability to protect against virus entry, replication, and release. Moreover, the results confirmed that EGCG and suramin can have synergistic effects against CHIKV strain S27 infection and two other clinical isolates of CHIKV. Our findings suggest that treatment with a combination of EGCG and suramin could provide a basis for the development of novel stretages against CHIKV infection.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 491, Issue 3, 23 September 2017, Pages 595-602
Journal: Biochemical and Biophysical Research Communications - Volume 491, Issue 3, 23 September 2017, Pages 595-602
نویسندگان
Jeng-Wei Lu, Po-Shiuan Hsieh, Chang-Chi Lin, Ming-Kuan Hu, Shih-Ming Huang, Yu-Ming Wang, Chun-Yu Liang, Zhiyuan Gong, Yi-Jung Ho,