Myelin basic protein stimulates plasminogen activation via tissue plasminogen activator following binding to independent l-lysine-containing domains

t-PA binds to Lys91 in the MBP NH2-terminal region and Pg binds to Lys122 in the MBP COOH-terminal region. This proximity promotes the activation of Pg by t-PA. The Pm generated may proteolyze MBP, displacing Pm from the surface which then is inhibited by α2-antiplasmin in the vicinity.257