کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5505507 1400271 2017 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Degradation of human Lipin-1 by BTRC E3 ubiquitin ligase
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Degradation of human Lipin-1 by BTRC E3 ubiquitin ligase
چکیده انگلیسی
Lipin-1 has dual functions in the regulation of lipid and energy metabolism according to its subcellular localization, which is tightly controlled. However, it is unclear how Lipin-1 degradation is regulated. Here, we demonstrate that Lipin-1 is degraded through its DSGXXS motif. We show that Lipin-1 interacts with either of two E3 ubiquitin ligases, BTRC or FBXW11, and that this interaction is DSGXXS-dependent and mediates the attachment of polyubiquitin chains. Further, we demonstrate that degradation of Lipin-1 is regulated by BTRC in the cytoplasm and on membranes. These novel insights into the regulation of human Lipin-1 stability will be useful in planning further studies to elucidate its metabolic processes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 488, Issue 1, 17 June 2017, Pages 159-164
نویسندگان
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