کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5505921 1400282 2017 23 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Overexpression of TACC3 is correlated with tumor aggressiveness and poor prognosis in prostate cancer
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Overexpression of TACC3 is correlated with tumor aggressiveness and poor prognosis in prostate cancer
چکیده انگلیسی
Transforming acidic coiled-coil (TACC3), a member of the TACC family, has been shown to be deregulated in various cancers and involved in tumor progression. However, its biological role and molecular mechanism in prostate cancer (PCa) have not been elucidated. Herein, we reported that TACC3 was markedly upregulated in metastatic PCa. The upregulation of TACC3 was significantly associated with the metastasis status, tumor stage, total prostate-specific antigen (PSA) level, and Gleason score in patients with PCa. Moreover, a Kaplan-Meier survival analysis showed that patients with PCa who had high TACC3 expression experienced shorter disease-free survival than patients with a low TACC3 expression. In addition, the knockdown of TACC3 dramatically reduced the migratory speed and invasiveness of PCa cells. Furthermore, silencing TACC3 markedly suppressed the Wnt/β-catenin signaling pathway. Taken together, these findings uncover a supportive role for TACC3 in PCa metastasis, which is mediated by the activation of the Wnt/β-catenin signaling pathway, suggesting that TACC3 may serve as a prognostic marker in patients with metastatic PCa.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 486, Issue 4, 13 May 2017, Pages 872-878
نویسندگان
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