کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5506042 | 1400284 | 2017 | 26 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The cytoplasmic translocation of Cx32 mediates cisplatin resistance in ovarian cancer cells
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The cytoplasmic translocation of Cx32 mediates cisplatin resistance in ovarian cancer cells The cytoplasmic translocation of Cx32 mediates cisplatin resistance in ovarian cancer cells](/preview/png/5506042.png)
چکیده انگلیسی
Ovarian cancer is the most lethal gynecologic malignancy, and cisplatin is one of the first-line chemotherapeutic agents. However, acquired cisplatin resistance prevents the successful treatment of patients with ovarian cancer. Gap junction (GJ) and connexin (Cx) are closely related to tumor formation, but the relationship between cisplatin resistance and GJ or Cx are undetermined. In this study, we established the cisplatin-resistant human ovarian cancer cell line A2780-CDDP. Here we showed that cisplatin resistance was correlated to the loss of GJ and the upregulation of Cx32 expression. Enhancing GJ in A2780-CDDP cells could increase the apoptotic response to cisplatin treatment. Furthermore, although Cx32 expression was increased in A2780-CDDP cells, it was more localized to the cytoplasm rather than in the membrane, and knockdown of Cx32 in A2780-CDDP cells sensitized them to cisplatin treatment. In summary, Cx32 is involved in cisplatin resistance, and cytoplasmic Cx32 plays an important role in chemoresistance.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 487, Issue 2, 27 May 2017, Pages 292-299
Journal: Biochemical and Biophysical Research Communications - Volume 487, Issue 2, 27 May 2017, Pages 292-299
نویسندگان
Weili Wu, Lixia Fan, Zeqing Bao, Yu Zhang, Yuexia Peng, Min Shao, Yuke Xiang, Xiaomin Zhang, Qin Wang, Liang Tao,