کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5506490 | 1536767 | 2016 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Enhancement of DEN-induced liver tumorigenesis in heme oxygenase-1 G143H mutant transgenic mice
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Enhancement of DEN-induced liver tumorigenesis in heme oxygenase-1 G143H mutant transgenic mice Enhancement of DEN-induced liver tumorigenesis in heme oxygenase-1 G143H mutant transgenic mice](/preview/png/5506490.png)
چکیده انگلیسی
In this study, we took advantage of transgenic mice which over-expressed HO-1 dominant negative mutant (HO-1 G143H) and observed its susceptibility to DEN-induced hepatocarcinogenesis. Our results indicate that HO-1 G143H mutant accelerates the progression of tumorigenesis and tumor growth. The mechanism is closely related to enhancement of ROS production which induce more hepatocytes death and secretion of inflammatory cytokines, proliferation of surviving hepatocytes. Our result provides the direct evidence that HO-1 plays an important protective role in liver carcinogenesis. Alternatively, we suggest the possible explanation on effect of HO-1 promoter polymorphism which involved in tumorigenesis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 481, Issues 1â2, 2 December 2016, Pages 169-175
Journal: Biochemical and Biophysical Research Communications - Volume 481, Issues 1â2, 2 December 2016, Pages 169-175
نویسندگان
Jianfeng Jin, Dayong Wang, Haifeng Xiao, Huiyan Wei, Cedric Matunda, He Zhang, Xin Li, Chuxuan Wang, Chaoxia Zou, Xu Gao, Weiming Zhao, Qiang Li,