کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5506930 | 1400306 | 2016 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
NSrp70 is significant for embryonic growth and development, being a crucial factor for gastrulation and mesoderm induction
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: NSrp70 is significant for embryonic growth and development, being a crucial factor for gastrulation and mesoderm induction NSrp70 is significant for embryonic growth and development, being a crucial factor for gastrulation and mesoderm induction](/preview/png/5506930.png)
چکیده انگلیسی
NSrp70 (nuclear speckle-related protein 70), a recently discovered protein and it belongs to the serine/arginine (SR) rich related protein family. NSrp70 is recognized as an important splicing factor comprising RNA recognition motif (RRM) and arginine/serine (RS)-like regions at the N- and C-terminus respectively, along with two coiled coil domains at each terminus. However, other functions of NSrp70 remain unelucidated. In this study, we investigated the role of NSrp70 in Xenopus embryogenesis and found that its maternal expression plays a critical role in embryonic development. Knockdown of NSrp70 resulted in dramatic reduction in the length of developing tadpoles and mild to severe malformation in Xenopus embryos. In addition, knockdown of NSrp70 resulted in an extremely short axis by blocking gastrulation and convergent extension. Further, animal cap assays along with activin A treatment revealed that NSrp70 is an essential factor for dorsal mesoderm induction as knockdown of NSrp70 caused a dramatic down-regulation of dorsal mesoderm specific genes and its loss significantly shortened the elongation region of animal caps. In conclusion, NSrp70 is crucial for early embryonic development, influencing gastrulation and mesoderm induction.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 479, Issue 2, 14 October 2016, Pages 238-244
Journal: Biochemical and Biophysical Research Communications - Volume 479, Issue 2, 14 October 2016, Pages 238-244
نویسندگان
Soo-Ho Lee, Chowon Kim, Hyun-Kyung Lee, Yoo-Kyung Kim, Tayaba Ismail, Youngeun Jeong, Kyungyeon Park, Mae-Ja Park, Do-Sim Park, Hyun-Shik Lee,