کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5508333 | 1537683 | 2017 | 50 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Browning deficiency and low mobilization of fatty acids in gonadal white adipose tissue leads to decreased cold-tolerance of transglutaminase 2 knock-out mice
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کلمات کلیدی
FABP4Tbx1PPARGTG2cell death-inducing DFFA-like effector atype II iodothyronine deiodinaseGLUT4TOM20DIO2ADIPOQLPLPRDM16BATRODZIC1FFAHSLTMEM26Ucp1 - UCP1Beige adipocytes - آدیوبیت های بژadiponectin - آدیپونکتینscAT - اسکاتFree fatty acid - اسید چرب آزادAdipose tissue - بافت چربیsubcutaneous white adipose tissue - بافت چربی زیر جلدیGonadal white adipose tissue - بافت چربی سفید گونادالWAT, White adipose tissue - بافت چربی سفید، بافت ادیپوز سفیدbrown adipose tissue - بافت چربی قهوه ایBrowning - براونینگTissue transglutaminase - ترانس گلوتامیناز بافتیrelative optical density - تراکم نسبی نسبیfold change - تغییر در برابرDifferentiation - تفکیکUncoupling protein-1 - جدا کردن پروتئین-1glucose transporter 4 - حمل کننده گلوکز 4PR domain containing 16 - دامنه PR حاوی 16Cold exposure - قرار گرفتن در معرض سردhormone sensitive lipase - لیپاز حساس به هورمونLipoprotein lipase - لیپو پروتئین لیپازfatty acid binding protein 4 - پروتئین اتصال دهنده اسید چرب 4uncoupling protein 1 - پروتئین جدا سازی 1transmembrane protein 26 - پروتئین غشایی 26WAT - چیCidea - کیدPeroxisome proliferator-activated receptor gamma - گاما گیرنده گیرنده فعال پرولیفیزوم فعال
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Browning deficiency and low mobilization of fatty acids in gonadal white adipose tissue leads to decreased cold-tolerance of transglutaminase 2 knock-out mice Browning deficiency and low mobilization of fatty acids in gonadal white adipose tissue leads to decreased cold-tolerance of transglutaminase 2 knock-out mice](/preview/png/5508333.png)
چکیده انگلیسی
During cold-exposure 'beige' adipocytes with increased mitochondrial content are activated in white adipose tissue (WAT). These cells, similarly to brown adipose tissue (BAT), dissipate stored chemical energy in the form of heat with the help of uncoupling protein 1 (UCP1). We investigated the effect of tissue transglutaminase (TG2) ablation on the function of ATs in mice. Although TG2+/+ and TG2â/â mice had the same amount of WAT and BAT, we found that TG2+/+ animals could tolerate acute cold exposure for 4Â h, whereas TG2â/â mice only for 3Â h. Both TG2â/â and TG2+/+ animals used up half of the triacylglycerol content of subcutaneous WAT (SCAT) after 3Â h treatment; however, TG2â/â mice still possessed markedly whiter and higher amount of gonadal WAT (GONAT) as reflected in the larger size of adipocytes and lower free fatty acid levels in serum. Furthermore, lower expression of 'beige' marker genes such as UCP1, TBX1 and TNFRFS9 was observed after cold exposure in GONAT of TG2â/â mice, paralleled with a lower level of UCP1 protein and a decreased mitochondrial content. The detected changes in gene expression of Resistin and Adiponectin did not provoke glucose intolerance in the investigated TG2â/â mice, and TG2 deletion did not influence adrenaline, noradrenaline, glucagon and insulin production. Our data suggest that TG2 has a tissue-specific role in GONAT function and browning, which becomes apparent under acute cold exposure.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids - Volume 1862, Issue 12, December 2017, Pages 1575-1586
Journal: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids - Volume 1862, Issue 12, December 2017, Pages 1575-1586
نویسندگان
András Mádi, Ixchelt Cuaranta-Monroy, Kinga Lénárt, Attila Pap, Zoltán András Mezei, Endre Kristóf, Anna Oláh, György Vámosi, Zsolt Bacsó, Péter Bai, László Fésüs,