Gaseous ligand selectivity of the H-NOX sensor protein from Shewanella oneidensis and comparison to those of other bacterial H-NOXs and soluble guanylyl cyclase

Heme Nitric oxide/OXygen binding protein from Shewanella oneidensis (So H-NOX) binds CO and NO with high affinities but shows no O2 binding under atmospheric pressure, although it does autoxidize. It exhibits multiple-step NO binding and its 6-coordinate NO complex converts to more stable 5-coordinate NO complex.122