Emerging role of Hippo signalling in pancreatic biology: YAP re-expression and plausible link to islet cell apoptosis and replication

Graphical depiction showing YAP signalling as a multifunctional pancreatic regenerative strategy in diabetes.(CTGF: Connective tissue growth factor, hEScs: Human embryonic stem cells, LATS1: Large tumour suppressor homolog 1, MOB1: MOB kinase activator 1, MST ½:mammalian STE20-like protein kinase 1/2, PPcs: Pancreatic progenitor cells, PSCs: Pleuripotent stem cells, SAV1: Salvador homolog 1, TAZ: Transcriptional co-activator with PDZ-binding motif, XIAP: X-linked inhibitor of apoptosis protein, YAP: Yes-associated protein).213