کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5509317 | 1538506 | 2017 | 40 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Phosphodiesterase 5 inhibition as a therapeutic target for ischemic stroke: A systematic review of preclinical studies
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کلمات کلیدی
Bcl-2bcl-2-like protein 4PDE5IMCAOBcl-xLBCCAo4-VO - 4-WOMAPK - MAPKAkt - آکتcerebrovascular disorder - اختلال مغزی و عضلانی4-vessel occlusion - انسداد رگ 4middle cerebral artery occlusion - انسداد شریان (سرخرگ) مغزی میانیPhosphodiesterase 5 inhibitor - بازدارنده فسفودی استراز 5Bax - باکسTerminal deoxynucleotidyl transferase dUTP nick end labeling - ترمینال deoxynucleotidyl transferase dUTP نام نهایی پایان نامهTUNEL - تونلbilateral common carotid artery occlusion - دو طرفه انسداد شریان کاروتید مشترکB-cell lymphoma 2 - لنفوم سلول B 2B-cell lymphoma-extra large - لنفوم سلول B-فوق العاده بزرگ استphosphodiesterase 5 inhibitors - مهار کننده های فسفودی استراز 5PDE5 inhibitor - مهارکننده PDE5protein kinase B - پروتئین کیناز Bmitogen-activated protein kinase - پروتئین کیناز فعال با mitogen
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Phosphodiesterase 5 inhibition as a therapeutic target for ischemic stroke: A systematic review of preclinical studies Phosphodiesterase 5 inhibition as a therapeutic target for ischemic stroke: A systematic review of preclinical studies](/preview/png/5509317.png)
چکیده انگلیسی
Phosphodiesterase 5 inhibitors (PDE5i), such as sildenafil (Viagra®) are widely used for erectile dysfunction and pulmonary hypertension. Preclinical studies suggest that PDE5i may improve functional outcome following ischemic stroke. In this systematic review we aimed to evaluate the effects of selective PDE5i in animal models of brain ischaemia. A systematic search in Medline, Embase, and The Cochrane Library was performed including studies in English assessing the effects of selective PDE5i. 32 publications were included describing outcome in 3646 animals. Neuroprotective effects of PDE5i were dependent on the NO-cGMP-PKG-pathway. These included reduced neuronal apoptosis (n = 3 studies), oxidative stress (n = 5), and neuroinflammation (n = 2). PDE5i increased angiogenesis and elevated regional cerebral blood flow in the ischemic penumbra, and improved functional recovery. Some studies found that PDE5i treatment reduced lesion volume (n = 9), others found no effect (n = 9). Treatment was effective when administered within 24 h post-ischemia, though treatment delayed to seven days improved outcome in one study. This review demonstrates both neuroprotective and neurorestorative effects of PDE5i in animal models of stroke, though the specific underlying signaling pathways relating to PDE5 inhibition and cGMP may remain serendipitous in some studies. There is currently limited evidence on the effects of selective PDE5i in human stroke patients, hence translation of preclinical results into clinical trials may be warranted.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cellular Signalling - Volume 38, October 2017, Pages 39-48
Journal: Cellular Signalling - Volume 38, October 2017, Pages 39-48
نویسندگان
Joakim N.E. Ãlmestig, Ida R. Marlet, Atticus H. Hainsworth, Christina Kruuse,