کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5510740 | 1539313 | 2017 | 22 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Metamorphosis and transition between developmental stages in European eel (Anguilla anguilla, L.) involve epigenetic changes in DNA methylation patterns
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
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![عکس صفحه اول مقاله: Metamorphosis and transition between developmental stages in European eel (Anguilla anguilla, L.) involve epigenetic changes in DNA methylation patterns Metamorphosis and transition between developmental stages in European eel (Anguilla anguilla, L.) involve epigenetic changes in DNA methylation patterns](/preview/png/5510740.png)
چکیده انگلیسی
The life history of the European eel (Anguilla anguilla, L.) is characterized by a series of metamorphoses and transitions that provoke drastic morphological changes. Most of these changes go along with the catadromous life cycle in eels, involving extensive physiologically adaptations. In this study it was investigated whether these drastic changes have an epigenetic basis by analyzing global methylation patterns in liver, gill and brain tissue from glass eels caught at the British coast as well as yellow and silver eels from River Rhine using methylation-sensitive amplified polymorphisms (MSAP). Analysis of molecular variance (AMOVA) on MSAP data derived from liver tissue revealed only minor differences in methylation patterns between glass, yellow and silver eels, reflecting uniform functioning of the liver throughout the investigated lifespan. In brain and gill tissue, however, marked differences in methylation patterns were found. Principal coordinates analysis (PCoA) revealed yellow eels being partially clustered with silver eels and a more distinct cluster of glass eels based on the methylation patterns in the brain. According to results found in the gills, glass eels were more similar to silver eels whereas yellow eels were found to be clustered separately. From these results it can be concluded that epigenetic changes in gill tissue most likely reflect and are linked with adaptation towards salt- and freshwater conditions. The observed differences in brain methylation patterns, however, might be linked to morphological and physiological changes during metamorphosis and transitions within the life history of European eels potentially affecting subsequent differential gene expression patterns required for such changes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Comparative Biochemistry and Physiology Part D: Genomics and Proteomics - Volume 22, June 2017, Pages 139-145
Journal: Comparative Biochemistry and Physiology Part D: Genomics and Proteomics - Volume 22, June 2017, Pages 139-145
نویسندگان
Jochen H. Trautner, Stefan Reiser, Tina Blancke, Katrin Unger, Klaus Wysujack,