کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5512923 | 1540628 | 2017 | 24 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Relationship between FGF21 and UCP1 levels under time-restricted feeding and high-fat diet
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کلمات کلیدی
FGF21LFDSCNHFDBATUcp1 - UCP1Adipose tissue - بافت چربیbrown adipose tissue - بافت چربی قهوه ایNutrition - تغذیهrestricted feeding - تغذیه محدودhigh-fat diet - رژیم غذایی با چربی بالاKetogenic diet - رژیم غذایی کتوژنیکlow-fat diet - رژیم غذایی کم چربیCircadian Clock - ساعت دیجیتالfibroblast growth factor 21 - فاکتور رشد فیبروبلاست 21Metabolism - متابولیسم Suprachiasmatic nucleus - هستههای سوپراکیاسماتیکuncoupling protein 1 - پروتئین جدا سازی 1WAT - چی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Fibroblast growth factor 21 (FGF21) exhibits a circadian oscillation, and its induction is critical during fasting. When secreted by liver and skeletal muscle, FGF21 enhances thermogenic activity in brown adipose tissue (BAT) by utilizing uncoupling protein 1 (UCP1) to dissipate energy as heat. Recently, it has been reported that UCP1 is not required for FGF21-mediated reduction in body weight or improvements in glucose homeostasis. As the relationship between FGF21 and UCP1 induction in tissues other than BAT is less clear, we tested the effect of restricted feeding (RF) and high dietary fat on FGF21 circadian expression and its correlation with UCP1 expression in liver and white adipose tissue (WAT). High dietary fat disrupted Fgf21 mRNA circadian oscillation but increased its levels in WAT. RF led to increased liver FGF21 protein levels, whereas those of UCP1 decreased. In contrast, WAT FGF21 protein levels increased under high-fat diet, whereas those of UCP1 decreased under RF. In summary, FGF21 exhibits circadian oscillation, which is disrupted with increased dietary fat. The relationship between FGF21 and UCP1 levels depends on the tissue and the cellular energy status.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Nutritional Biochemistry - Volume 40, February 2017, Pages 116-121
Journal: The Journal of Nutritional Biochemistry - Volume 40, February 2017, Pages 116-121
نویسندگان
Nava Chapnik, Yoni Genzer, Oren Froy,