کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5513826 1541432 2017 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
ReviewMetabolic interactions with cancer epigenetics
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
ReviewMetabolic interactions with cancer epigenetics
چکیده انگلیسی

Cancer cells have epigenetic alterations that are known to drive cancer progression. The reversibility of the epigenetic posttranslational modifications on chromatin and DNA renders targeting these modifications an attractive means for cancer therapy. Cellular epigenetic status interacts with cell metabolism, and we are now beginning to understand the nature of how this interaction occurs and the biological contexts that mediate its function. Given the tremendous interest in understanding and targeting metabolic reprogramming in cancer, this nexus also provides opportunities for exploring the liabilities of cancers. This review summarizes recent developments in our understanding of the interaction of cancer metabolism and epigenetics.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular Aspects of Medicine - Volume 54, April 2017, Pages 50-57
نویسندگان
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