کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5515160 | 1541828 | 2017 | 6 صفحه PDF | دانلود رایگان |
- Incubation of cue-induced reinstatement of cocaine seeking in C57BL/6J mice
- Transient incubation of context-induced cocaine or sucrose seeking
- No incubation of cue-induced reinstatement of sucrose seeking
Prior studies have shown that drug-seeking behaviors increase, rather than dissipate, over weeks to months after withdrawal from drug self-administration. This phenomenon - termed incubation - suggests that drug-craving responses elicited by conditioned environmental or discrete cues may intensify over pronged abstinence. While most of this work is conducted in rats with intravenous drug self-administration models, there is less evidence for incubation in mice that have greater utility for molecular genetic analysis and perturbation. We tested whether incubation of cocaine-seeking behavior is evident in C57BL/6J mice following 3Â weeks (5Â days/week) of cocaine self-administration in 2Â h self-administration sessions. We compared cocaine-seeking (drug-paired lever) responses 1, 7, or 28Â days after withdrawal from cocaine self-administration, and over similar times following sucrose pellet self-administration. We found that the initial re-exposure to the self-administration test chambers elicited increased reward-seeking behavior in both sucrose and cocaine self-administering mice, with maximal responses found at 7Â days compared to 1 or 28Â days after self-administration with either reinforcer. However, following extinction training, reinstatement of cocaine seeking reinforced by response-contingent presentation of reward-associated cues (tone/light) was significantly higher after 28Â days compared to 1 or 7Â days following cocaine self-administration. In contrast, cue-induced reinstatement of sucrose-paired lever pressing did not increase over this time frame, demonstrating a drug-specific incubation effect not seen with a natural reward. Thus, C57BL/6J mice display incubation of cue-induced reinstatement of cocaine seeking similar to findings with rats, but only show a transient incubation of context-induced cocaine seeking.
Journal: Pharmacology Biochemistry and Behavior - Volume 159, August 2017, Pages 12-17