کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5515176 1541829 2017 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effects of anandamide administration on components of reward processing during free choice
ترجمه فارسی عنوان
اثرات استفاده از آنانداماید بر اجزای پردازش پاداش در انتخاب آزاد
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی


- Anandamide is an endogenous cannabinoid thought to play a role in reward and feeding.
- Subcutaneous injections of anandamide preceded behavioral testing in a free choice task.
- Anandamide led to a significant shift in preference toward the less effortful, optimal option.
- Anandamide effects could involve shifts in hedonics, appetitive strategies and decision-making.

Previous research has implicated the positive modulation of anandamide, an endocannabinoid neurotransmitter, on feeding behavior. Anandamide is particularly noteworthy as it acts as an endogenous ligand of the CB1 receptor, the same receptor that is activated by tetrahydrocannabinol, the primary psychoactive component in Cannabis sativa. Cannabis legalization in North America has presented with a need to study endocannabinoid agonists and their effects on behavior. Much has yet to be determined in terms of the role of the endocannabinoid system in decision-making scenarios. The research presented here tested the hypothesis that anandamide would augment motivation and reward processing via appetitive and consummatory measures during an operant, foraging task. A three-box design was used in order to provide the animals with a free choice, exploratory foraging environment. Discrimination, preference, and incentive contrast were analyzed as discrete measures of decision-making in the three-box paradigm. Anandamide administration (1 mg/kg) was found to significantly increase motivation for the optimal foraging outcome and alter basic processing of reward information involved in discrimination and relative valuation. The positive effects of anandamide on eating behavior and motivation have implications toward possible treatment modalities for patient populations presenting with disorders of motivation. These findings suggest the need for continued investigation of the endocannabinoid system as a central component of motivated behavior.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacology Biochemistry and Behavior - Volume 158, July 2017, Pages 14-21
نویسندگان
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