CYP1A1 MspI polymorphism and cancer susceptibility among Latinos: A meta-analysis

- Meta-analysis of CYP1A1 MspI polymorphism and cancer susceptibility for Latinos
- Meta-analysis includes 11,677 Latino subjects (4783 cases & 6894 controls).
- Overall cancer risk is increased with the MspI polymorphism for Latinos.
- MspI polymorphism augments the risk for mainly for Leukemia.

BackgroundMany studies and meta-analyses have examined the association between the CYP1A1 MspI polymorphism and cancer risk, yielding conflicting results and lacking a specific focus on the Latino population. Our objective was to determine the association between the MspI polymorphism and cancer risk for Latinos.MethodsPubMed, OVID, Wiley, SCOPUS, EBSCO and LILACS databases and retrieved studies' bibliographies were searched for case-control studies that investigated the association between the MspI polymorphism and cancer among Latinos until December 2015. Genotype distributions were extracted and crude odds ratios (OR) were calculated. Depending on the level heterogeneity, determined by the ψ2-based Q-test and the I2-test, Fixed-Effects or Random-Effects models were used to calculate the pooled ORs and 95% CI for the heterozygous, homozygous, dominant, recessive, and allelic genetic models. No publication bias was detected by the Begg-Mazumdar's test and Egger's test.ResultsThirty-six publications (38 studies) from 372 publications were included (4742 cases and 6778 controls). Overall, all genetic models demonstrated an association between the MspI polymorphism and cancer risk for Latinos: Heterozygous [OR = 1.21 (95% CI: 1.02-1.43)], Homozygous [OR = 1.48 (95% CI: 1.10-1.99)], Dominant [OR = 1.19 (95% CI: 1.01-1.41)], Recessive [OR = 1.34 (95% CI: 1.03-1.74)], and Allelic [OR = 1.22 (95% CI: 1.05-1.43). When stratified by cancer, a positive association was only observed for leukemia for the homozygous [OR = 2.82 (95% CI: 1.07-7.40)], Dominant [OR = 1.65 (955CI: 1.06-6.55)], Recessive [OR = 2.57 (95% CI: 1.01-6.55)], and Allelic genetic models [OR = 1.69 (95% CI: 1.05-2.73)].ConclusionThis meta-analysis demonstrates that the overall risk for cancer development is augmented by the CYP1A1 MspI polymorphism for the Latino population, more specifically for leukemia.