Association of rs1801582 and rs1801334 PARK2 Polymorphisms with risk of Parkinson's disease: A case-control study in South India and Meta-Analysis

BackgroundParkinson's disease (PD) is a multi-factorial autosomal recessive disease that affects basal ganglia of the human brain.MethodsA case-control study of 70 PD and 70 controls in South Indian population was performed to screen rs1801582 and rs1801334 polymorphisms in PARK2 gene using ARMS-PCR and DNA sequencing methods. Additionally, we have performed a systematic meta-analysis of both the polymorphisms from the previously reported genetic association studies in PD.ResultsThe genotypic frequency (GG) of rs1801582 was higher in cases [57.5% (40/70)] compared to controls [48.57% (34/70)], whereas the frequency of rs1801334 (GG) in PD [57.14% (40/70)] was lower than in controls [58.57% (41/70)]. Though, there were frequency variations in the polymorphisms, it does not attain minimal statistical significance. In meta-analysis, significant association was noticed between PD and rs1801582 for allelic OR = 0.78, (95% CI [0.70-0.86]), homozygote OR = 0.61, (95% CI [0.43-0.86]), dominant OR = 0.75, (95% CI [0.62-0.90]) and recessive OR = 0.67, (95% CI [0.48-0.94]) models. However, no association was noticed for rs1801334 in all the genetic models.ConclusionOverall, our investigation suggests that rs1801582 is significantly associated with PD susceptibility, whereas rs1801334 have no association in the studied populations. Hence, larger studies are required to obtain conclusive outcomes.