کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5530667 1549390 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Research paperHypoxia inducible factor 1α: A critical factor for the immune response to pathogens and Leishmania
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Research paperHypoxia inducible factor 1α: A critical factor for the immune response to pathogens and Leishmania
چکیده انگلیسی


- Many pathogens directly induce the stabilization of HIF-1α.
- HIF-1α may have immunosuppressive effects on cells of the immune system.
- HIF-1α expression is required for survival inside the host's cell by Leishmania.
- HIF-1α inhibits dendritic cell functions and the development of T cell responses.

Organisms typically react to foreign pathogens by initiating an inflammatory response. However, in order to limit inflammatory tissue injury, it is essential for the organism to maintain the balance between inflammatory and anti-inflammatory responses. Dysregulation of this process can result in the strong inhibition of protective pro-inflammatory responses, and ultimately in pathogen persistence. Chronic infections are often associated with inflammation and tissue disruption. Inflamed tissues are characterized by low levels of oxygen and glucose, a microenvironment that triggers the stabilization of the hypoxia-inducible transcription factor HIF-1α. HIF-1α is the master regulator of the response to hypoxia. Here, we review the role of HIF-1α in the immune response to various pathogens and we highlight how certain microorganisms, including Leishmania parasites, have evolved to hijack the HIF-1 pathway to their advantage.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cellular Immunology - Volume 309, November 2016, Pages 42-49
نویسندگان
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