کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5534860 1551362 2017 23 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The role of barrier function, autophagy, and cytokines in maintaining intestinal homeostasis
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
The role of barrier function, autophagy, and cytokines in maintaining intestinal homeostasis
چکیده انگلیسی
Intestinal homeostasis is maintained through the interplay of the intestinal mucosa, local and systemic immune factors, and the microbial content of the gut. The cellular processes of autophagy, endoplasmic reticulum stress, the unfolded protein response and regulation of reactive oxygen species production are required to maintain a balance between pro-inflammatory responses against potential pathogens and a tolerogenic response towards commensal bacteria. Intestinally active cytokines regulate innate immune pathways and cellular pathways within the gut mucosa. Disruption of these processes, or alterations in the cytokine milieu, can result in an improper response to the commensal gut microbial community leading to inappropriate inflammation characteristic of conditions such as inflammatory bowel disease.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Cell & Developmental Biology - Volume 61, January 2017, Pages 51-59
نویسندگان
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