Keywords: IRE1a; AMPK; 5â² adenosine monophosphate-activated protein kinase; AT; adipose tissue; BECN1; beclin 1; Bcl-2; B-cell lymphoma 2; Bim; Bcl-2-like protein 11 (BCL2L11); BMI; body mass index; CAD; coronary artery disease; CCS; Canadian Cardiovascular Society; CHO
مقالات ISI IRE1a (ترجمه نشده)
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Keywords: IRE1a; ASC; apoptosis-associated speck-like protein containing a CARD; ATF6; activating transcription factor 6; CHOP; C/EBP homologous protein; DAMPs; damage-associated molecular patterns; gAcrp; globular adiponectin; HBSS; Hank's balanced salt solution; HO-1;
Keywords: IRE1a; ATF4; activating transcription factor 4; ATF6α; activating transcription factor 6α; BIP; binding immunoglobulin protein; C/EBPδ; CCAAT-enhancer-binding protein delta; CSC; cancer stem cell; ER; endoplasmic reticulum; IRE1α; inositol-requiring enzyme-1
Keywords: IRE1a; AGO; Argonaute; ARG1; arginase1; ATM; adipose tissue macrophage; BAT; brown adipose tissue; BMDM; bone marrow derived macrophage; C/EBP; CCAAT-enhancer-binding proteins; CCL2; C-C Motif Chemokine Ligand 2; CCR2; C-C Motif Chemokine Receptor 2; CLS; crown-
Keywords: IRE1a; PGMO; Pre-gestational maternal obesity; PGMN; Pre-gestational maternal normal weight; HUVECs; Human umbilical vein endothelial cells; NO; Nitric oxide; NOS; Nitric oxide synthase; eNOS; endothelial nitric oxide synthase; Akt; Protein kinase B/Akt; ER; end
Keywords: IRE1a; T2DM; Type 2 diabetes mellitus; WAT; White adipose tissue; APJ; angiotensin II protein J receptor; GPCRs; G-protein couple receptors; DN; diabetic nephropathy; WHO; World Health Organization; T2DM; type 2 diabetes mellitus; CVD; cardiovascular disease; BM
Keywords: IRE1a; 4-PBA; 4-phenylbutyric acid; ARA; arachidonic acid; ATF6; activating transcription factor 6; BiP or Grp78; 78-kDa glucose regulated protein; COX; cyclooxygenase; CYP; cytochrome P450; DHA; docosahexaenoic acid; eIF2α; eukaryotic translation initiation fa
27-hydroxycholesterol: A novel player in molecular carcinogenesis of breast and prostate cancer
Keywords: IRE1a; 27-OHC; 27-hydroxycholesterol; ADT; androgen deprivation therapy; AR; androgen receptor; ATF4; Activating Transcription Factor 4; ATF6; Activating Transcription Factor 6; C/EBP; CCAAT / Enhancer binding proteins; CHOP; C/EBP homologous protein; CIP2A; can
Keywords: IRE1a; AA; Angelica Archangelica; AGNHW; AnGongNiuHuang Wan; AM; Astragalus membranaceus; AMP; adenosine monophosphate; AMPK; adenosine 5â²-monophosphate activated protein kinase; Ang II; angiotensin II; AP; Astragalus polysaccharide; ASIV; astragaloside IV; AS
Keywords: IRE1a; ER stress; KSHV; IRE1α; PERK; Primary effusion lymphoma; Unfolded protein response; ATF6; activating transcription factor-6; CHOP; CCAAT/enhancer-binding protein-homologous protein; ER; endoplasmic reticulum; GADD34; growth arrest and DNA damage gene-34;
Keywords: IRE1a; DC; dendritic cell; ER; endoplasmic reticulum; IDO; indoleamine 2,3-dioxygenase; IFN-γ; interferon gamma; iNOS; inducible nitric oxide synthase; IRE1α; inositol-requiring enzyme 1 alpha; MAPK; mitogen-activated protein kinase; PD1; programmed death 1; P
Keywords: IRE1a; Unfolded protein response; Myeloid cells; T cells; Inflammation; Cell-nonautonomous; Tumor microenvironment; APC; antigen presenting cells; ATF6; activating transcription factor 6; CHOP; CCAAT/-enhancer binding protein homologous protein; DC; dendritic ce
Keywords: IRE1a; ATF4; activating transcription factor-4; ATF6α; activating transcription factor-6α; EB1; end binding protein-1; EDEM; ER degradation-enhancing α-like protein; ER; endoplasmic reticulum; ERAD; ER-associated degradation; GCN2; general control non-derepre
Keywords: IRE1a; Omega-6:omega-3; Nonalcoholic fatty-liver disease; High-fat diet; α-Linolenic acid; Colitis; Murine model; 4-HNE; 4-hydroxy-2-nonenal; AA; arachidonic acid; ALA; alpha-linolenic acid; ATF6; activating transcription factor 6; BiP; binding immunoglobulin p
Keywords: IRE1a; ER; endoplasmic reticulum; UPR; unfolded protein response; AD; Alzheimer's disease; APP; amyloid precursor protein; GRP78/BiP; chaperone glucose-regulated protein 78; PERK; protein kinase RNA (PKR)-like ER kinase; ATF6; activating transcription factor 6;
Keywords: IRE1a; ATF6; activating transcription factor 6; BiP; heat shock 70 kDa protein 5 (glucose-regulated protein, 78 kDa); GSMA; gel shift mobility assay; HO-1; heme oxygenase 1; IL-1β; interleukin 1 beta; IRE1α; inositol-requiring protein 1; NF-κB; nuclear fact
Keywords: IRE1a; ATF4; activating transcription factor 4 (also designated as CREB-2, cAMP response element (CRE) binding protein2); ATF6; activating transcription factor 6; BSA; bovine serum albumin; CHOP; CCAAT/enhancer-binding protein-homologous protein; CNS; central ne
Keywords: IRE1a; AEC; alveolar epithelial cell; AT2; alveolar epithelial type II; AM; alveolar macrophage; ARE; antioxidant response element; BALF; bronchoalveolar lavage fluid; JNK; c-Jun N-terminal kinase; EGFR; epidermal growth factor receptor; ECM; extracellular matri
TSPA as a novel ATF6α translocation inducer efficiently ameliorates insulin sensitivity restoration and glucose homeostasis in db/db mice
Keywords: IRE1a; ATF6α; ER stress; Insulin resistance; TSPA; T2DM; Akt; protein kinase B; ATF6; activating transcription factor 6; CHOP; C/EBP-homologous protein; CNX; calnexin; CRT; calreticulin; CREB; cAMP response element binding protein; ER; Endoplasmic reticulum; ER
Targeting the enhanced ER stress response in Marinesco-Sjögren syndrome
Keywords: IRE1a; Marinesco-Sjögren syndrome; ER stress; Lymphoblastoid cell line; Tunicamycin; Apoptosis; Tauroursodeoxycholic acid; 4-PBA; sodium phenylbutyrate; ATF6α; activating transcription factor 6α; CASP3; caspase-3; DEXA; dexamethasone; EBV; Epstein-Barr virus;
Real-Time and Non-invasive Monitoring of the Activation of the IRE1α-XBP1 Pathway in Individuals with Hemodynamic Impairment
Keywords: IRE1a; Endoplasmic reticulum stress; Unfolded protein response; Acute kidney injury; Cardiopulmonary bypass; XBP1; IRE1α;
Inhibition of ER stress-related IRE1α/CREB/NLRP1 pathway promotes the apoptosis of human chronic myelogenous leukemia cell
Keywords: IRE1a; Chronic myelogenous leukemia; Endoplasmic reticulum stress; Apoptosis; IRE1α; NLRP1 inflammasome;
Oxidants produced by methylglyoxal-modified collagen trigger ER stress and apoptosis in skin fibroblasts
Keywords: IRE1a; AGE; Advanced glycation end product; ATF4; Activating transcription factor 4; BID; BH3 interacting-domain death agonist; CHOP; CCAAT-enhancer-binding protein homologous protein; COL1A1; Collagen type I α1-chain; DAPI; 4',6-diamidino-2-phenylindole; ECM;
Long-term exposure to high-sucrose diet down-regulates hepatic endoplasmic reticulum-stress adaptive pathways and potentiates de novo lipogenesis in weaned male mice
Keywords: IRE1a; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; ChREBP; carbohydrate-responsive element-binding protein; SREBP-1c; sterol regulatory element-binding protein 1c; SCD1; stearoyl-CoA desaturase-1; FASN; fatty acid synthase; CPT-1α; carnitine palmitoyltrans
Zingiber officinale extract administration diminishes steroyl-CoA desaturase gene expression and activity in hyperlipidemic hamster liver by reducing the oxidative and endoplasmic reticulum stress
Keywords: IRE1a; ATP binding cassette transporter G5/G8; Endoplasmic reticulum stress; Ginger extract; Paraoxonase 1; Stearoyl CoA desaturases; Steatotic liver; ABCG5/G8; ATP-binding cassette sub-family G member 5/8; ACC; acetyl-CoA carboxylase; ATF6α; activating transcr
Sevoflurane postconditioning improves the spatial learning and memory impairments induced by hemorrhagic shock and resuscitation through suppressing IRE1α-caspase-12-mediated endoplasmic reticulum stress pathway
Keywords: IRE1a; Hemorrhagic shock and resuscitation; Sevoflurane postconditioning; Endoplasmic reticulum stress; IRE1α; Caspase-12; Spatial learning and memory;
Protein tyrosine phosphatase 1B regulates endothelial endoplasmic reticulum stress; role in endothelial dysfunction
Keywords: IRE1a; Shear stress; Nitric oxide; Protein kinase RNA-like endoplasmic reticulum kinase; Mesenteric resistance artery; Ach; Acetylcholine; ATF6; Activated Transcription Factor 6; BAX; Bcl-2-Associated X Protein; BCL2; B-Cell Lymphoma 2; CHOP; C/EBP Homologous
XBP1 activation enhances MANF expression via binding to endoplasmic reticulum stress response elements within MANF promoter region in hepatitis B
Keywords: IRE1a; MANF; mesencephalic astrocyte-derived neurotrophic factor; XBP1; X-box binding protein-1; TM; tunicamycin; ERSE; ER stress-responsive elements; UPR; unfolded protein response; IRE1α; inositol-requiring 1α; LPS; lipopolysaccharide; Mesencephalic astrocyt
Gap junctional intercellular communication and endoplasmic reticulum stress regulate chronic cadmium exposure induced apoptosis in HK-2 cells
Keywords: IRE1a; AKT; protein kinase B; ASK1; apoptosis signal-regulating kinase 1; ER; endoplasmic reticulum; GJIC; gap junctional intercellular communication; IRE1α; inositol-requiring enzyme 1; ROS; reactive oxygen species; UPR; unfolded protein response; XBP-1s; spli
Endoplasmic reticulum stress precedes oxidative stress in antibiotic-induced cholestasis and cytotoxicity in human hepatocytes
Keywords: IRE1a; Ac-DEVD-AMC; N-acetyl-Asp-Glu-Val-Asp-7-amido-4-methylcoumarin; AKT; protein kinase B; AMP; ampicillin; ATB; antibiotic; ATF6; activating transcription factor 6; BC; bile canaliculi; BSEP; bile salt export pump; CDF; 5(6)-carboxy-2,7-dichlorofluorescein;
A promising natural product, pristimerin, results in cytotoxicity against breast cancer stem cells in vitro and xenografts in vivo through apoptosis and an incomplete autopaghy in breast cancer
Keywords: IRE1a; 7-AAD; 7-amino-actinomycin D; ABC; ATP-binding cassette; AEC; 3-amino-9-ethyl carbazole; ATD; acute toxicity determination; Atg5; autophagy protein 5; ATP; adenosine-5â²-triphosphate; BCL-2; B-cell lymphoma 2; Bip/GRP78; binding immunoglobulin protein/78
Fasting exacerbates hepatic growth differentiation factor 15 to promote fatty acid β-oxidation and ketogenesis via activating XBP1 signaling in liver
Keywords: IRE1a; GDF15; growth differentiation factor 15; UPR; unfolded protein response; IRE1α; inositol requiring enzyme 1 alpha; XBP1; x-box binding protein 1; STZ; streptozotocin; ChIP; chromatin immunoprecipitation; ERSE; ER stress-response element; Ppara; peroxisom
Targeting autophagy enhances apatinib-induced apoptosis via endoplasmic reticulum stress for human colorectal cancer
Keywords: IRE1a; Tyrosine kinase inhibitor; Chloroquine; IRE1α; Drug resistance;
ER stress and cancer: The FOXO forkhead transcription factor link
Keywords: IRE1a; Endoplasmic reticulum; ER stress; Cancer; FOXO; Forkhead transcription factors; Unfolded protein response; AKT; Protein Kinase B; AKT1; Protein Kinase B Alpha; AMPK; AMP-activated protein kinase; ASK1; Apoptosis Signal Regulated Kinase 1; ATF4; Activating
Antiproliferative effect of p-Coumaric acid targets UPR activation by downregulating Grp78 in colon cancer
Keywords: IRE1a; Cancer chemoprevention; Colon cancer; p-Coumaric acid; Grp78 (78â¯kDa glucose regulated protein); ER stress; Apoptosis; Grp78; 78â¯kDa glucose regulated protein; DMH; dimethylhydrazine; PERK; protein kinase R-like ER kinase; IRE1α; inositol-requiring e
Binge ethanol exposure induces endoplasmic reticulum stress in the brain of adult mice
Keywords: IRE1a; Alcohol use isorder; Brain damage; Endoplasmic reticulum tress; mTOR signaling; Neurodegeneration; Oxidative stress; ATF6; Activating transcription factor 6; IRE1α; Inositol-requiring kinase.; PERK; Protein kinase RNA-like endoplasmic reticulum kinase.;
Autophagy in ischemic stroke
Keywords: IRE1a; 3-MA; 3-methyladenine; Aβ; amyloid β; AIF; apoptosis-inducing factor; Akt; protein kinase B; AMPK; AMP-activated protein kinase; ATF6; activating transcription factor 6; Atg; autophagy-related genes; ATP; adenosine 5â²-triphosphate; BBB; blood-brain ba
Experimental Nonalcoholic Steatohepatitis and Liver Fibrosis Are Ameliorated by Pharmacologic Activation of Nrf2 (NF-E2 p45-Related Factor 2)
Keywords: IRE1a; NASH; Nrf2; TBE-31; ACACA; acetyl-CoA carboxylase alpha; ACLY; ATP citrate lyase; ACOT7; acetyl-CoA thioesterase 7; ACOX2; acetyl-CoA oxidase 2; ADRP; adipose differentiation-related protein; AP-1; activator protein 1; ApoB; apolipoprotein B; ATF4; activa
Pyruvate kinase M1 interacts with A-Raf and inhibits endoplasmic reticulum stress-induced apoptosis by activating MEK1/ERK pathway in mouse insulinoma cells
Keywords: IRE1a; ER; endoplasmic reticulum; FACS; fluorescence-activated cell sorting; IRE1α; inositol-requiring enzyme 1α; PERK; protein kinase R-like ER kinase; PKM1; pyruvate kinase muscle isoform 1; T2D; type 2 diabetes mellitus; TUNEL; terminal deoxynucleotidyl tra
Molecular cloning and characterization of unfolded protein response genes from large yellow croaker (Larimichthys crocea) and their expression in response to dietary fatty acids
Keywords: IRE1a; ATF6; activating transcription factor-6; ATF4; activating transcription factor 4; BiP/GRP78; immunoglobulin heavy chain binding protein/glucose-regulated protein 78; CHOP; C/EBP homologous protein; ER; endoplasmic reticulum; ERAD; ER-associated protein de
Curcumin attenuates oxidative stress induced NFκB mediated inflammation and endoplasmic reticulum dependent apoptosis of splenocytes in diabetes
Keywords: IRE1a; STZ; streptozotocin; ER; endoplasmic reticulum; IRE1α; serine/threonine-protein kinase/endoribonuclease 1α; ATF6; activating transcription factor 6; PERK; protein kinase R (PKR)-like endoplasmic reticulum kinase; MAPK; mitogen activated protein kinase;
Osteogenesis imperfecta: new genes reveal novel mechanisms in bone dysplasia
Keywords: IRE1a; ADAMTS; A disintegrin and metalloprotease with thrombospondin motifs; AR-OI; autosomal recessive osteogenesis imperfecta; ATF6; activating transcription factor 6; ATGL; adipose triglyceride lipase; BiP; binding immunoglobulin protein; BMDD; bone mineraliz
Cyperus amuricus induces G1 arrest and apoptosis through endoplasmic reticulum stress and mitochondrial signaling in human hepatocellular carcinoma Hep3B cells
Keywords: IRE1a; ATF6; activating transcription factor 6; C. amuricus:; Cyperus amuricus; CDKIs; cyclin-dependent kinases inhibitors; CDKs; cyclin-dependent kinases; CHOP; C/EBP-homologous protein; DAPI; 4â²,6-diamidino-2-phenylindole; eIF2α; eukaryotic initiation facto
The role of barrier function, autophagy, and cytokines in maintaining intestinal homeostasis
Keywords: IRE1a; IEC; intestinal epithelial cell; TJ; tight junctions; IBD; inflammatory bowel disease; ER; endoplasmic reticulum; UPR; unfolded protein response; CD; Crohn's disease; IL; Interleukin; NOD2; nucleotide-binding oligomerization domain-containing protein
ER stress disturbs SR/ER-mitochondria Ca2Â + transfer: Implications in Duchenne muscular dystrophy
Keywords: IRE1a; ATF6; activating transcription factor 6; ATP; Adenosine triphosphate; CTL; Control; Ddit3; DNA damage inducible transcript 3; DMD; Duchenne Muscular Dystrophy; EDL; Extensor Digitorum Longus; EIF2α; eukaryotic translation initiation factor 2A; FBS; fetal
Inflammasomes and type 2 diabetes: An updated systematic review
Keywords: IRE1a; AIM; Absent In Melanoma; ASC; Apoptosis-associated Speck-like protein; ATF6; Activating Transcription Factor 6; CARD; Caspase Activation and Recruitment Domain; DAMPs; Damage Associated Molecular Patterns; DIO; Diet Induced Obese; IAPP; Islet Amyloid Poly
Ageing sensitized by iPLA2β deficiency induces liver fibrosis and intestinal atrophy involving suppression of homeostatic genes and alteration of intestinal lipids and bile acids
Keywords: IRE1a; ACC; acetyl-CoA carboxylase; ATF6; activating transcription factor6; AB-PAS; alcian blue-periodic acidschiff; ACC; acetyl-CoA carboxylase; ACSL; long-chain acyl-CoA synthetase; Bad; Bcl-2-associated death promoter; Bax; Bcl-2-like protein 4; Bcl-2; B-cell
IRE1α links Nck1 deficiency to attenuated PTP1B expression in HepG2 cells
Keywords: IRE1a; ATF6; activating transcription factor 6; EGFR; epidermal growth factor receptor; ER; endoplasmic reticulum; HNF4α; hepatocyte nuclear factor 4α; GAP; GTPase-activating protein; HFD; high fat diet; IL-4; interleukin-4; IRE1α; inositol-requiring enzyme 1
Oxidative stress drives CD8+ T-cell skin trafficking in patients with vitiligo through CXCL16 upregulation by activating the unfolded protein response in keratinocytes
Keywords: IRE1a; Oxidative stress; unfolded protein response; CXCL16; CXCR6; CD8+ T cells; skin migration; DAPI; 4â²-6-Diamidino-2-phenylindole; eIF2α; Eukaryotic initiation factor 2α; ER; Endoplasmic reticulum; HSPA5; Heat shock 70-kDa protein 5; IRE1α; Inositol-requ
Targeting chaperones, heat shock factor-1, and unfolded protein response: Promising therapeutic approaches for neurodegenerative disorders
Keywords: IRE1a; 17-AAG; 17-(allylamino)-17-demethoxygeldanamycin (tanespimycin); 17-DMAG; 17- dimethylaminoethylamino-17-demethoxygeldanamycin (alvespimycin); AAV; adeno-associated virus; Aβ; amyloid-β; AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; APP;