کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5860539 | 1133190 | 2013 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Exposure to inhaled particulate matter activates early markers of oxidative stress, inflammation and unfolded protein response in rat striatum
ترجمه فارسی عنوان
قرار گرفتن در معرض ذرات استنشاقی نشانگرهای زودرس استرس اکسیداتیو، التهاب و پاسخ پروتئین باز شدن در موش صحرایی را فعال می کند
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کلمات کلیدی
NF-κBHO-1IL-1βATF6NRF-2inositol-requiring protein 1BiP - BIPIRE1α - IRE1ainterleukin 1 beta - اینترلوکین 1 بتاnuclear factor (erythroid-derived 2)-like 2 - فاکتور هسته ای (erythroid-derived 2) -like 2nuclear factor kappa-light-chain-enhancer of activated B cells - فاکتور هسته ای kappa-light-chain-enhancer از سلول های B فعال شده استactivating transcription factor 6 - فعال کردن عامل رونویسی 6heme oxygenase 1 - همای اکسیژناز 1Polycyclic aromatic hydrocarbons - هیدروکربن آروماتیک چندحلقهایPAHs - هیدروکربن های آروماتیک چند حلقه ایPERK - پرک
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی
To study central nervous system airborne PM related subchronic toxicity, SD male rats were exposed for eight weeks to either coarse (32 μg/m3), fine (178 μg/m3) or ultrafine (107 μg/m3) concentrated PM or filtered air. Different brain regions (olfactory bulb, frontal cortex, striatum and hippocampus), were harvested from the rats following exposure to airborne PM. Subsequently, prooxidant (HO-1 and SOD-2), and inflammatory markers (IL-1β and TNFα), apoptotic (caspase 3), and unfolded protein response (UPR) markers (XBP-1S and BiP), were also measured using real-time PCR. Activation of nuclear transcription factors Nrf-2 and NF-κB, associated with antioxidant and inflammation processes, respectively, were also analyzed by GSMA. Ultrafine PM increased HO-1 and SOD-2 mRNA levels in the striatum and hippocampus, in the presence of Nrf-2 activation. Also, ultrafine PM activated NF-κB and increased IL-1β and TNFα in the striatum. Activation of UPR was observed after exposure to coarse PM through the increment of XBP-1S and BiP in the striatum, accompanied by an increase in antioxidant response markers HO-1 and SOD-2. Our results indicate that exposure to different size fractions of PM may induce physiological changes (in a neuroanatomical manner) in the central nervous system (CNS), specifically within the striatum, where inflammation, oxidative stress and UPR signals were effectively activated.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology Letters - Volume 222, Issue 2, 24 October 2013, Pages 146-154
Journal: Toxicology Letters - Volume 222, Issue 2, 24 October 2013, Pages 146-154
نویسندگان
R. Guerra, E. Vera-Aguilar, M. Uribe-Ramirez, G. Gookin, J. Camacho, A.R. Osornio-Vargas, V. Mugica-Alvarez, R. Angulo-Olais, A. Campbell, J. Froines, T.M. Kleinman, A. De Vizcaya-Ruiz,