کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5546549 | 1402747 | 2016 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
PBPK modeling and simulation in drug research and development
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موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
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چکیده انگلیسی
202 Physiologically based pharmacokinetic (PBPK) modeling has developed rapidly in the last decade within both the field of academia and the pharmaceutical industry, and has become an integral tool in drug discovery and development. In this review, the concept and methodology of PBPK modeling are briefly introduced. Several case studies were discussed based on our work about how PBPK modeling and simulation (M&S) can be utilized through various stages of drug discovery and development. The regulatory acceptance and industrial practices around PBPK modeling and simulation is also discussed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Acta Pharmaceutica Sinica B - Volume 6, Issue 5, September 2016, Pages 430-440
Journal: Acta Pharmaceutica Sinica B - Volume 6, Issue 5, September 2016, Pages 430-440
نویسندگان
Xiaomei Zhuang, Chuang Lu,