کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5546554 1402747 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effect of age on the pharmacokinetics of polymorphic nimodipine in rats after oral administration
ترجمه فارسی عنوان
اثر سن بر روی فارماکوکینتیک نیمی دیپین پلی مورفیک در موشهای صحرائی بعد از مصرف خوراکی
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
چکیده انگلیسی

The previous investigation has proved that their existed pharmacokinetic difference between the different crystal forms of the polymorphic drugs after oral administration. However, no systemic investigations have been made on the change of this pharmacokinetic difference, resulted either from the physiological or from the pathological factors. In this paper, we used polymorphic nimodipine (Nim) as a model drug and investigated the effect of age difference (2- and 9-month old) on the pharmacokinetics after oral delivery in rats. As the results shown, for L-form of Nim (L-Nim), the AUC0-24 h in 2-month-old rats was 343.68±47.15 ng·h/mL, which is 23.36% higher than that in 9-month-old rats. For H-form of Nim (H-Nim), the AUC0-24 h in 2-month-old rats was 140.91±19.47 ng·h/mL, which is 54.64% higher than that in 9-month-old rats. The AUC0-24 h ratio between H-Nim and L-Nim was 2.44 in 2-month-old rats and 3.06 in 9-month-old rats. Since age difference could result in unparallelled change of the absorption and bioavailability of the polymorphic drugs, the results in this experiment are of value for further investigation of crystal form selection in clinical trials and rational clinical application of the polymorphic drugs.

In this paper, polymorphic nimodipine (Nim) was used as a model drug to investigate the effect of age difference (2- and 9-month old) on the pharmacokinetics after oral delivery in rats. Since age difference could result in unparalleled change of the absorption and bioavailability of the polymorphic drugs, the results in this experiment are of value for further investigation of crystal form selection in clinical trials and rational clinical application of the polymorphic drugs.171

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Acta Pharmaceutica Sinica B - Volume 6, Issue 5, September 2016, Pages 468-474
نویسندگان
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