Glycyrrhizic acid attenuates myocardial injury: Involvement of RIP140/NF-kB Pathway

The present study was designed to evaluate the protective effect of Glycyrrhizic acid (GA) on isoproterenol (ISO)-induced myocardial cardiotoxicity both in rats. Serum was detected for myocardial injury parameters. Heart tissues were prepared for histopathology, oxidative stress, inflammation biomarkers as well as western blot analysis. Results showed that pretreatment with GA apparently decreased levels of myocardial CK-MB and LDH, and alleviated histopathological changes induced by ISO injection. GA exerted the cardioprotective effect via restoring super oxide dismutase (SOD), malondialdehyde (MDA) and Pro-inflammatory. Meanwhile, it should be noted that GA restored RIP140/NF-kB in rat hearts which was evidenced by the western Blot analysis. The results from histopathological examination were further supported the cardioprotective findings of GA.