کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5552783 1557950 2017 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Agmatine for combined treatment of epilepsy, depression and cognitive impairment in chronic epileptic animals
ترجمه فارسی عنوان
آگماتین برای درمان ترکیبی صرع، افسردگی و اختلال شناختی در حیوانات صرع مزمن
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی تومور شناسی
چکیده انگلیسی
Epilepsy is fourth most common neurological disorders associated with depression and cognitive deficits. As per present scenario, none of the antiseizure drugs have been reported successful to have ameliorative effect on epilepsy associated depression and cognitive deficits. Thus, the study was envisioned to assess an ameliorative potential of agmatine on epilepsy and its efficacy and safety for management of associated depression and cognitive deficits. The animals were made epileptic employing pentylenetetrazole (35 mg/kg i.p. every 48 ± 2 h) kindling model of epilepsy and subsequently were treated with vehicle, valproic acid (300 mg/kg/day i.p.) and agmatine (2.5, 5, and 10 mg/kg)/day/i.p. for 15 days. Except naïve, all the groups were challenged with same pentylenetetrazole dose as employed during kindling on days 5, 10, and 15 to evaluate seizure severity. Two hours after seizure severity test, tail suspension test and passive shock avoidance paradigm was employed to evaluate depression and cognitive behavior respectively. Results suggested that epileptic animals were significantly associated with depression and cognitive impairment. Chronic valproate treatment significantly reduced seizure severity, but was found unable to mitigate depression and cognitive deficits. However, agmatine treatment dose dependently ameliorated seizure severity as well as associated depression and cognitive deficits. On 15th day, animals were euthanized and pertinent neurochemical estimations were carried out in cortical and hippocampal areas of the mice brain. Thus, study concluded that agmatine ameliorated seizure severity, depression and cognitive impairment in epileptic animals, possibly via restoring glutamate-GABA neurotransmission and serotonin synthesis with decreased nitrosative stress.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomedicine & Pharmacotherapy - Volume 92, August 2017, Pages 720-725
نویسندگان
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