کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5553277 1557953 2017 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Phytochemicals of Pogostemon Cablin (Blanco) Benth. aqueous extract: Their xanthine oxidase inhibitory activities
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی تومور شناسی
پیش نمایش صفحه اول مقاله
Phytochemicals of Pogostemon Cablin (Blanco) Benth. aqueous extract: Their xanthine oxidase inhibitory activities
چکیده انگلیسی

Bioassay-guided fractionation of the aerial part of P. cablin revealed that fraction A3 of the water extract exhibited significant xanthine oxidase inhibitory activities (IC50 = 85.42 ± 1.71 μg/mL), which further led to the isolation of ten more bioactive compounds, including two new compounds (1 and 2). The structures of compounds 1 and 2 were elucidated by extensive spectral analysis. It is revealed that flavonoids and phenolic compounds were found to be responsible for the xanthine oxidase inhibitory activities of P. cablin. Especially, rosmarinic acid was found to be with potent XO inhibitory activity (IC50 = 8.53 ± 0.91 μg/mL).

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomedicine & Pharmacotherapy - Volume 89, May 2017, Pages 544-548
نویسندگان
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