Aryl hydrocarbon receptor activation modulates CD8αα+TCRαβ+ IELs and suppression of colitis manifestations in mice

The results suggest that AhR activation ameliorated DSS-induced acute colitis, in a manner that is associated with the local expansion and functions of CD8αα+TCRαβ+ IELs in acute colitis. The findings indicate that AhR-related ligands might be targeted as novel drug targets for IBD.