کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5555338 1559749 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Role of phyto-stabilised silver nanoparticles in suppressing adjuvant induced arthritis in rats
ترجمه فارسی عنوان
نقش نانوذرات نقره با ثبات فیتواستروژن در سرکوب آرتروز ناشی از کمپنی در موش صحرایی
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
چکیده انگلیسی


- Silver nanoparticles synthesized using aqueous extract of Piper nigrum L has potential anti-arthritic effects
- At low doses the phyto-stabilized silver nanoparticles reversed the articular damage and paw edema induced by CFA
- Its anti arthritic effect is mediated by suppression of TNF-α and transcription factor NF-kβ p65.
- The low toxicity of phytostabilised silver nanoparticles suggests a new therapeutic rationale for arthritis.

Aim of the studyThe present study was aimed to evaluate the anti-arthritic effects of silver nanoparticles synthesised using Piper nigrum extract and to further establish its mechanism of action in a rat model of adjuvant induced arthritis (AA).Materials and methodsAdjuvant arthritis was induced by injecting complete Freund's adjuvant (0.1 mL) into the left hind paw of 36 albino Wistar rats (n = 6). Silver nanoparticles stabilised with Piper nigrum extract (25 and 50 mg/kg). Commercial silver nanoparticles (50 mg/kg) and methotrexate (0.1 mg/kg) were administered by intraperitoneal route from day 11 to day 22 on alternate days.ResultsIt was found that treatment with silver nanoparticles stabilised with Piper nigrum (S-AgNPs) significantly reduced the paw edema and alleviated the histopathological changes of cell infiltration, synovial hyperplasia, bone and cartilage destruction. Furthermore, the phytostabilised silver nanoparticles (S-AgNPs) inhibited the protein expression of NF-kβ p65 and TNF-α as evidenced by immunohistochemistry analysis.ConclusionOur current findings suggest that silver nanoparticles stabilised with Piper nigrum extract (S-AgNPs) have potent anti-arthritic activity which is mediated by inhibition of TNF-α and suppression of pro-inflammatory cytokines that are secreted in response to activated transcription factors of NF-kβ.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Immunopharmacology - Volume 41, December 2016, Pages 17-23
نویسندگان
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