کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5555505 1559743 2017 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Expansion of monocytic myeloid-derived suppressor cells in endometriosis patients: A pilot study
ترجمه فارسی عنوان
گسترش سلول های سرکوبگر مونوسیتی مولکول های مولکولی در بیماران مبتلا به آندومتریوز: یک مطالعه آزمایشی
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
چکیده انگلیسی


- An abnormal expansion of monocytic myeloid-derived suppressor cells (M-MDSCs) in endometriosis patients
- M-MDSCs from endometriosis patients significantly suppressed T cells response.
- Endometriosis-derived M-MDSCs produced high level of reactive oxygen species (ROS)

Endometriosis is a chronic inflammation disease and is closely associated with immune dysregulation. Myeloid-derived suppressor cells (MDSCs) are a negative regulator of the immune system. The aim of this study was to evaluate the possible role of MDSCs in endometriosis patients. We collected the peripheral blood and peritoneal fluid from endometriosis patients and controls and analyzed M-MDSCs level using specific monoclonal antibodies recognizing HLA-DR, CD33, CD11b, CD14 markers by flow cytometry. We found that there existed abnormal expansion of monocytic MDSCs (M-MDSCs) (HLA-DR−/lowCD33+ CD11b+ CD14+) in peripheral blood and peritoneal fluid of patients with endometriosis. Functional studies revealed that M-MDSCs from endometriosis patients significantly suppressed T-cell responses and produced high level of reactive oxygen species (ROS). The elevation of M-MDSCs from endometriosis patients may contribute to the disease progression.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Immunopharmacology - Volume 47, June 2017, Pages 150-158
نویسندگان
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