کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5557778 1560939 2016 21 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Targeting tumor tolerance: A new hope for pancreatic cancer therapy?
ترجمه فارسی عنوان
هدف قرار دادن تحمل تومور: امید جدید به درمان سرطان پانکراس چیست؟
کلمات کلیدی
سرطان پانکراس، ایمونوتراپی، مدولاسیون ایمنی، ایمونولوژی سرطان، استروما مرتبط با تومور، ایمنی فزاینده،
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
چکیده انگلیسی

With a 5-year survival rate of just 8%, pancreatic cancer (PC) is projected to be the second leading cause of cancer deaths by 2030. Most PC patients are not eligible for surgery with curative intent upon diagnosis, emphasizing a need for more effective therapies. However, PC is notoriously resistant to chemoradiation regimens. As an alternative, immune modulating strategies have recently achieved success in melanoma, prompting their application to other solid tumors. For such therapeutic approaches to succeed, a state of immunologic tolerance must be reversed in the tumor microenvironment and that has been especially challenging in PC. Nonetheless, knowledge of the PC immune microenvironment has advanced considerably over the past decade, yielding new insights and perspectives to guide multimodal therapies. In this review, we catalog the historical groundwork and discuss the evolution of the cancer immunology field to its present state with a specific focus on PC. Strategies currently employing immune modulation in PC are reviewed, specifically highlighting 66 clinical trials across the United States and Europe.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacology & Therapeutics - Volume 166, October 2016, Pages 9-29
نویسندگان
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