کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5558337 1561133 2017 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Rebamipide ameliorates radiation-induced intestinal injury in a mouse model
ترجمه فارسی عنوان
ربامایپید باعث کاهش آسیب روده ناشی از تابش در مدل موش می شود
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی


- The first study on the therapeutic effects of rebamipide in radiation injury.
- Irradiation destructed microscopic structures and intestinal barrier.
- Rebamipide recovered intestinal barrier function and tight junction components.
- Rebamipide reduced the levels of pro-inflammatory cytokines and MMP 9.
- Intestinal cell proliferation and β-catenin expression increased by rebamipide.

Radiation-induced enteritis is a major side effect in cancer patients undergoing abdominopelvic radiotherapy. Radiation exposure produces an uncontrolled inflammatory cascade and epithelial cell loss leading to impaired epithelial barrier function. The goal of this study was to determine the effect of rebamipide on regeneration of the intestinal epithelia after radiation injury. The abdomens of C57BL/6 mice were exposed to 13 Gy of irradiation (IR) and then the mice were treated with rebamipide. Upon IR, intestinal epithelia were destroyed structurally at the microscopic level and bacterial translocation was increased. The intestinal damage reached a maximum level on day 6 post-IR and intestinal regeneration occurred thereafter. We found that rebamipide significantly ameliorated radiation-induced intestinal injury. In mice treated with rebamipide after IR, intestinal barrier function recovered and expression of the tight junction components of the intestinal barrier were upregulated. Rebamipide administration reduced radiation-induced intestinal mucosal injury. The levels of proinflammatory cytokines and matrix metallopeptidase 9 (MMP9) were significantly reduced upon rebamipide administration. Intestinal cell proliferation and β-catenin expression also increased upon rebamipide administration. These data demonstrate that rebamipide reverses impairment of the intestinal barrier by increasing intestinal cell proliferation and attenuating the inflammatory response by inhibiting MMP9 and proinflammatory cytokine expression in a murine model of radiation-induced enteritis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology and Applied Pharmacology - Volume 329, 15 August 2017, Pages 40-47
نویسندگان
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